The aim of the keynote is to describe the innovations in cloud management brought by the OpenNebula Cloud Toolkit. This widely used open-source Cloud manager fits into existing data centers to build private, public and hybrid Infrastructure-as-a-Service (IaaS) Clouds. Most of its innovative features have been developed to address requirements from business use cases in RESERVOIR, flagship of European research initiatives in virtualized infrastructures and cloud computing. The innovations comprise support for elastic multi-tier services; flexible and scalable back-end for virtualization, storage and networking management; and support for Cloud federation and interoperability. The presentation ends with an introduction of the community and ecosystem that are evolving around OpenNebula and the new European project on cloud computing infrastructures that are using this innovative cloud technology.